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February 16, 2017
Everything About Cannabinoids
March 10, 2017
CBD Tolerance
CBD Tolerance – Although not much research has been done on someone’s CBD tolerance, from what is available the tolerance of CBD is different than a THC tolerance. After repetitive use of THC one builds a tolerance where their body does not feel the effects as potent.
When one feels muted effects a tolerance break is often taken to renew the body to feel more potent effects.
CBD and THC Difference
The most prominent difference between CBD and THC is the psychoactive properties. As we all know, THC provides the user with a psychoactive high; CBD does not. This is because CBD has a low affinity to CB1 and CB2 receptors.
The Study
It is known that a repetitive consumption of THC leads to an increase in tolerance to the effects one feels after consumption. Several studies have shown this to be true but does the consumer build up a tolerance on non-psychoactive cannabinoids like CBD? This study looks at whether CBD provides a tolerance to neuroprotective and pharmacological effects.
Methods
Male mice were split into two groups where they were given THC and CBD immediately before and three hours after cerebral ischemia. One group received this treatment after a 14 day repeated treatment.
Key Findings
- 3.1. Neuroprotective effects of Δ9-THC but not cannabidiol were inhibited by the CB1 antagonist
- 3.2. Repeated treatment with Δ9-THC but not cannabidiol developed tolerance to the neuroprotective and hypothermic effect
- 3.4. Repeated treatment with Δ9-THC but not with cannabidiol reversed the increase in cerebral blood flow
- 3.5. Repeated treatment with Δ9-THC but not cannabidiol decreased the expression of CB1 receptor protein in MCA occluded mice
During this study it was shown that consecutive use of cannabidiol or CBD, one will not develop a tolerance of the non-psychoactive cannabinoid. Although other cannabinoids like THC build up tolerance in the body this study proves that does not apply to all cannabinoids. In another study, results prove that a tolerance to CBD does not develop. The way one develops a tolerance for THC is different than a tolerance of CBD.
12 Comments
Not being a mouse, I can tell you that I develop a tolerance to CBD in a matter of a week or so, to the point that CDB basically becomes a placebo for me. If I stop using CBD for a couple weeks, I get a beneficial effect from it again, but daily use of CBD will pretty soon again cause a tolerance of CBD such that taking CBD becomes an expensive and useless endeavor for me. By the way, my dosages have been in the range of 1.5 mg to 6 mg per day (taken in the evening at or near bedtime).
ad I said, anxiolitic effect of CBD derive from agonism to 5ht1a receptor that is not a cannabinoid receptor.
Of course cannabinoid receptor is not downregulated by cbd because it’s a cannabinoid antagonist: cbd fights cannabinoid tolerance but probably reduce 5ht1a tolerance
Some research shows at micro doses of CBD the body will produce endocannabinoid receptors as well! There is still lots of research that needs to be done and on dosing as well!
I’ve tried multiple times to find if there’s a gained tolerance to CBD but have yet to find anything conclusive. The double blind mouse test is a good one, but inconclusive. That being said I have been using CBD for a minute and haven’t felt any negative effects.
Dr. Dustin Sulak D.O., says “Research has shown that small doses of cannabinoids from cannabis can signal the body to make more endocannabinoids and build more cannabinoid receptors.” This means when taken in small doses overtime, you will have produced more endocannabinoids and their receptors, actually increasing ones sensibility.
https://www.ncbi.nlm.nih.gov/m/pubmed/22083592/
Every substance develop a certain amount of tolerance, including CBD. It doesn’t mean that you cannot get benefits from that substance if you still consumes it continously, but it depends on the purpose. As or CBD, if the purpose is (for example) anxiety control, long term use can nave a negative effect in an acute stress experience, because CB-n receptors are not the main receptor implied for the powerful CBD effects… You look at the wrong receptor! CBD works through 5ht1a receptor which have antipsychotic, ansiolitic and antidepressant effects, and you certainly develop tolerance to that receptor.
November 28, 2017
Hey Jessie I have been searching the Web everywhere and I found this post. I believe we have similar issue I hope you can read this. Did you used to smoke weed then stop then use alot of cbd and now you can’t get high? Because that’s what I think happened to me.. I quit weed for a year used cbd for a year and now this is what happens. I get a good buzz in the morning but then by the late afternoon no matter how much I thc I consume I can’t get creative there is no euphoria and I just feel like wired normal it’s making worry..
Thanks for your feedback, Jesse. We often find different people have different reactions to CBD and other Cannabinoids. We have found profound research to suggest that it not so much your tolerance as it is your body’s memory of how it feels. That being said, we have some customers that insist that their 10mg per day dose is more then enough with no need of increasing.
Don’t believe this, I myself am living proof that you can develop a tolerance to CBD.
How do you avoid this?
Simple.
Don’t overuse it. Cut back a little, maybe take a break.