21 Jul 2017
Studies show relation between CBD and bone growth.

How Does CBD Affect Bone Growth and Development?

CBD and Bone Growth

Breaking a bone and waiting for it to heal correctly is a long process that takes patience. Research shows that cannabinoids, including CBD, increase bone growth but also bone density. This is all because of the endocannabinoid system. Cannabinoids work on receptors in the endocannabinoid system to produce bone formations. Research even shows that we have a skeletal endocannabinoid system that works directly with our bones.

Bone fractures are one of the leading injuries today. Both men and women of all ages experience bone fractures throughout their life. As a child, our bones are stronger but as we get older, they can start to degenerate. Sometimes we’ll fall out of a tree while climbing, overextend your leg while achieving a game-winning point, or twist your ankle in a pair of heels. No matter how you fractured your bone, making sure it heals correctly is extremely important to your health.

How a Bone Fracture Heals

Bone fractures heal on their own. It is important to keep a balanced diet and stay healthy while your bones are repairing. Various minerals and vitamins are found in foods that will help promote bone growth.

Once the fracture has occurred one will experience an inflammation stage where a blood clot will form. Cytokines then begin to repair cells into the fracture gap. These cells will turn into specialized cells to create osteoblasts which produce new cells that lay down new bone and cartilage. These osteoblasts produce protein to create a soft callus which will harden over time. Finally, as the bone fully heals osteoblasts and osteoclasts will weave the bone with bone formation cells and bone resorption cells. During this process, the bone will rebuild itself.

CBD and Bone Growth Research

A 2009 study concludes that in age-related osteoporosis, cannabinoid receptors will increase peak bone mass and bone marrow. Osteoporosis is defined as the loss of bone mass and bone tissue, creating weak bones. It is oftentimes in older people, specifically women due to smaller bones and menopause.

Observations throughout the study demonstrate that the CB1 receptor regulates peak bone mass through effects of osteoclasts, bone resorption and age-related bone loss. This means that the administered CBD helped to strengthen the fracture callus; the cartilage which mends the fracture. The CB1 receptor is therefore unique in that it regulates peak bone mass through an effect on osteoclast activity, but protects against age-related bone loss by regulating bone cells.

In one of the most recent studies, results show that CBD alone specifically helps with healing bone fractures. Tel Aviv University specifically examined the bone health with isolated CBD or a combination with THC; a group of mice were administered CBD or THC and CBD. Results concluded that isolated CBD has better effects than when the two cannabinoids were in combination.

During this study the results concluded that CBD alone enhanced the biochemical properties of healing in a fracture. CBD involves changes to the organic matrix of bones that affects the flexibility and toughness. Multiple experiments were complete to isolate the various effects of how CBD helps with bone growth. Findings show the callus has an increase in strength and toughness from CBD which is explained by osteoblastic bone formation.

Endocannabinoid System and Bone Growth

Most of us are familiar with the endocannabinoid system but there is also a skeletal cannabinoid system that works with your bones. Some of the key components found in the endocannabinoid system are also located in our bones. Anandamide and 2AG are believed to be sourced in the skeleton and produced by osteoblasts and osteoclasts. CBD interacts with these cannabinoid receptors to return back to homeostasis.

Anandamide: an endocannabinoid neurotransmitter that regulates pain, sleep, memory, reproduction, movement and cognition.
2AG: a main endocannabinoid that reacts on the CB receptors in the central and peripheral nervous system. 2AG regulates appetite, pain management and the immune system.

These studies demonstrate how CBD and bone growth relate. Due to our skeletal endocannabinoid system, CBD is able to send signals to our bone cells. It is important to maintain a healthy lifestyle while your bones are healing so they can heal properly. CBD helps with bone growth to strengthen the bone by triggering osteoblasts.

Once you get older your bone will begin to deteriorate causing your bones to become brittle, making it easier to fracture. Old age can also come with bone diseases that create a block in bone growth. Getting through life with a bone disease like osteoporosis typically means relying on medications to provide relief. Prescription medications can come with harsh side effects that make you feel even worse. Turning to a natural cannabinoid will eliminate having to take medications that provide poor side effects. Research shows direct correlation in CBD and bone growth.



  1. I’m at a point where I need to decide if I’m going the conventional or CBD route to treat my osteoporosis. Can you advise on the type, amount, and frequency of cbd application?

    1. Hi Basia,
      Thank you for reaching out to us today! We offer many products that contain 99% pure CBD Isolate and help to relieve things like pain, inflammation, anxiety, stress, insomnia, lack of appetite, depression, and much more! On our website, you will find that we offer capsules, tinctures, topicals, and gummies that would provide great benefits. It is up to you on how you want to consume CBD and this is why we offer a variety of delivery methods for our customers to choose from.
      We recommend a starting dose of 1mg per 10lbs of body weight. For example, if you weigh 140lbs, you would want to start off taking 14mg of CBD. This is just our starting dose so you can always increase if you feel like you aren’t experiencing enough relief. You can also spread the dose out throughout the day or take it all at once, depending on the effects you feel and how often you need it. You cannot overdose and your body will filter our the CBD that isn’t needed or used. We hope this information is helpful! Let us know if you have any further questions.

  2. How long does it take to see a difference in bone healing? I had a fusion in my foot that is not taking, so we are now trying cbd.

    1. Hi Margaret,
      Thank you for reaching out to us today! CBD helps to strengthen bone by triggering osteoblasts to produce new cells. CBD also helps to relieve symptoms such as pain, inflammation, stress, insomnia, lack of appetite, and much more. Everyone’s body reacts to CBD differently, and so we cannot determine how long it will take for you to see specific results in bone healing. Maintaining a healthy lifestyle is also an important factor while your bones are healing so they can heal properly so that is something to take into account. If you try our products, please let us know how your CBD experience goes. We would love to hear how CBD is helping in your bone healing!

  3. I’ve been taking cbd to help with inflamation. seems to help a lot. But I do have bone spurs growing on my spinal vertebrae. Will the cbd stimulate further growth of the spurs?

  4. I have been taking CBD oil for 6 weeks. At my latest Dexa scan, my numbers in my spine increased by 3 points and I am now at a 2.5. A 2.4 is no longer a classification of osteoporosis. I was diagnosed at age 40 and am now 58. My numbers have never increased. My only change….cbd oil. On a side note, I have been using reclast infusion for the past three years. I am going to use it one more time. If my numbers increase at my appointment next year, no more meds for me!

    1. Wow this is awesome Theresa! We would love to share your story for the world to read. Please let us know and we will reach out.

    2. You don’t have evidence since you were doing the reclast infusions. It’s NOT a side note. You can’t count this as evidence for CBD.

    3. What strength is your CBD oil ? Is it a tincture? Last what doses are you taking?

  5. Have there been any studies with regard to spinal fusions?

    1. Not specifically but check out our stories page and one customer used CBD after spinal fusion surgery.

      1. Can you tell me about cbd for after spinal fusion

  6. Pease direct me to the research studies to share with my MD I am already dealing at 59yrs with the pharmaceuticals and I want off

    1. Research articles are linked within each blog.

  7. This is great info thx I just started taking cbd oil for sleep but i also have osteoporsis n dont want to take the med.. because of the many serious side effects so now i will take cbd oil n hope for the best .. Im a female 69 years of age.. hope it works for me………

    1. March 20, 2018
      Thank you for your post. It would be great to know your progress with the cbd oil. I’m 67 and trying to decide which route to take with my osteoporosis. My sister, 65 just started Forteo and I’m not interested in any of the prescription meds. After chemo, radiation etc. though the drugs probably save my life I’d rather have something not attached to Big Pharma especially if it works!

    2. I am just wondering how this is working for you. Being as you only started this in February, you may not know the answer yet. How did you go about getting this oil, where is it sold? I am also small boned, have osteoporis, and have just broken my ankle. I am the same age as you. Would you recommend this, and did you talk to your MD about it first?


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