What is CBD With No THC?
Infinite CBD • April 22, 2019
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Not being a mouse, I can tell you that I develop a tolerance to CBD in a matter of a week or so, to the point that CDB basically becomes a placebo for me. If I stop using CBD for a couple weeks, I get a beneficial effect from it again, but daily use of CBD will pretty soon again cause a tolerance of CBD such that taking CBD becomes an expensive and useless endeavor for me. By the way, my dosages have been in the range of 1.5 mg to 6 mg per day (taken in the evening at or near bedtime).
Cycling your amount of CBD is said to be beneficial for this.
I’ve tried multiple times to find if there’s a gained tolerance to CBD but have yet to find anything conclusive. The double blind mouse test is a good one, but inconclusive. That being said I have been using CBD for a minute and haven’t felt any negative effects.
Some research shows at micro doses of CBD the body will produce endocannabinoid receptors as well! There is still lots of research that needs to be done and on dosing as well!
Every substance develop a certain amount of tolerance, including CBD. It doesn’t mean that you cannot get benefits from that substance if you still consumes it continously, but it depends on the purpose. As or CBD, if the purpose is (for example) anxiety control, long term use can nave a negative effect in an acute stress experience, because CB-n receptors are not the main receptor implied for the powerful CBD effects… You look at the wrong receptor! CBD works through 5ht1a receptor which have antipsychotic, ansiolitic and antidepressant effects, and you certainly develop tolerance to that receptor.
https://www.ncbi.nlm.nih.gov/m/pubmed/22083592/
Dr. Dustin Sulak D.O., says “Research has shown that small doses of cannabinoids from cannabis can signal the body to make more endocannabinoids and build more cannabinoid receptors.” This means when taken in small doses overtime, you will have produced more endocannabinoids and their receptors, actually increasing ones sensibility.
ad I said, anxiolitic effect of CBD derive from agonism to 5ht1a receptor that is not a cannabinoid receptor.
Of course cannabinoid receptor is not downregulated by cbd because it’s a cannabinoid antagonist: cbd fights cannabinoid tolerance but probably reduce 5ht1a tolerance
Don’t believe this, I myself am living proof that you can develop a tolerance to CBD.
How do you avoid this?
Simple.
Don’t overuse it. Cut back a little, maybe take a break.
Thanks for your feedback, Jesse. We often find different people have different reactions to CBD and other Cannabinoids. We have found profound research to suggest that it not so much your tolerance as it is your body’s memory of how it feels. That being said, we have some customers that insist that their 10mg per day dose is more then enough with no need of increasing.
November 28, 2017
Hey Jessie I have been searching the Web everywhere and I found this post. I believe we have similar issue I hope you can read this. Did you used to smoke weed then stop then use alot of cbd and now you can’t get high? Because that’s what I think happened to me.. I quit weed for a year used cbd for a year and now this is what happens. I get a good buzz in the morning but then by the late afternoon no matter how much I thc I consume I can’t get creative there is no euphoria and I just feel like wired normal it’s making worry..